1000L Online Liquid Preparation Skid 316L Sanitary Mixing Vessel with Load-Cell Weighing, CIP Spray Ball and Sanitary Diaphragm Outlet for Injection Lines
Product Overview This 1000 L blending vessel is supplied as a ready-to-connect preparation skid rather than a bare tank, so it can be dropped into a parenteral or ophthalmic liquid line with minimum on-site piping work. Load cells under the sanitary legs give continuous in-process mass readout, letting operators dose raw material and solvent by weight instead of relying on level marks. All product-side connections use hygienic diaphragm valves and clamp fittings arranged for full drainability, and the whole assembly — vessel, agitator, spray device, instrumentation and local control panel — is pre-mounted on a single stainless steel frame, factory-assembled and pressure tested before shipment.
Technical Parameters
Parameter
Specification
Parameter
Specification
Rated Capacity
1000 L (geometric), typical fill 70–80%
Wetted Alloy
AISI 316L stainless steel, low-carbon grade
Frame & Cladding
AISI 304 stainless steel, sanitary leg design
Surface Finish (product side)
Electro-polished, Ra ≤ 0.4 μm, passivated
Surface Finish (outer)
Fine satin finish, easy-clean profile
Vessel Configuration
Vertical, dished or conical bottom, self-draining
Jacket
Full dimple or half-pipe jacket, insulated and clad
Temperature Range
2 °C to 140 °C depending on utility selected
Agitator Drive
Bottom-entry magnetic coupling, 0–500 rpm inverter range
Impeller Options
Hydrofoil, pitched-blade or anchor type per viscosity
Weighing
3–4 load cells, 0.1% FS accuracy, weight display on HMI
Cleaning
Rotating spray ball, coverage ratio ≥ 1.5, low-point drain
Sterilization
SIP-ready design, drainable jacket and product cavity
Seals
EPDM / FKM / PTFE per FDA 21 CFR 177 requirement
Control
PLC with colour touch HMI, recipe and batch data storage
Electrical
380 V / 50 Hz or to customer's local supply
Standards
GMP sanitary design, PED / ASME on request
Process Advantages
Weight-based dosing: Load-cell weighing removes the error of graduated level reading, so each batch is reproducible and automatically recorded for batch documentation.
Seal-free agitation: The magnetic coupling transmits torque without a shaft penetrating the product cavity, eliminating mechanical seal leakage and the associated seal-flush utility.
One vessel, two thermal duties: The jacket handles both warming for dissolution and cooling for intermediate holding, removing the need for a separate tempering tank.
Skid-mounted delivery: Piping, valves, instruments and control panel are assembled and tested in our workshop, so on-site work is limited to utility hook-up and commissioning.
Drainable by design: Conical or dished bottom with a low-point outlet ensures no liquid pocket remains after discharge or cleaning.
Key Applications
Formulation Blending: Homogeneous mixing of excipients and API stock at controlled speed to avoid foaming and shear.
Buffer & Rinse Preparation: On-demand preparation of WFI-based buffer, rinse and cleaning solutions with weight-tracked composition.
Temperature Holding: Jacket-controlled holding of prepared solution within a defined band prior to filtration.
Pilot & Scale-up Trials: Reproducible weight-based recipes make the unit usable for both production and process development.
Frequently Asked Questions (FAQs)
Q: Is the tank supplied as a complete skid or as a standalone vessel? A: Both options are available. The standard delivery is a skid-mounted unit with agitator, spray ball, valves, instruments and control panel pre-installed and tested; a bare vessel can also be supplied if you have your own piping contractor.
Q: How accurate is the weighing system and can it be calibrated? A: The load-cell arrangement delivers approximately 0.1% full-scale accuracy and supports calibration with test weights; calibration records can be provided as part of the documentation package.
Q: Which impeller should I select for my product? A: Hydrofoil impellers suit low-viscosity solutions and give strong turnover with low shear; pitched-blade types handle moderate viscosity and suspension; anchor types are used when wall sweeping is needed. Send us your product viscosity and we will recommend the matching configuration.
Q: Can the control system record batch data for audit purposes? A: Yes. The PLC and touch HMI store recipe parameters, weight, temperature and operator actions, and support multi-level user permission, so batch records can be retrieved during internal review or inspection.
Quality Assurance & After-Sales
Each vessel is subject to material verification, dimensional inspection, weld endoscopic check, hydrostatic testing and surface finish measurement before release. Supplied documents include material traceability certificates, passivation and roughness reports, test records, general arrangement drawings, P&ID, electrical diagrams and an operation and maintenance manual in English. Installation supervision, on-site commissioning and operator training can be arranged, and spare seal kits, spray balls and load cells are held in stock for fast dispatch.