Liquid Vial Filling Machine for 1-20ml Glass Bottles

Vial liquid filling machines designed for 1-20ml glass bottles represent a critical component in pharmaceutical manufacturing, offering automated solutions for precise and efficient liquid dispensing. These machines combine advanced filling technologies with intelligent control systems to meet stringent industry standards while optimizing production throughput.

Core Filling Capabilities

Modern vial filling machines for this volume range employ multiple filling mechanisms to accommodate different fluid viscosities and pharmaceutical requirements. Piston pump systems provide mechanical precision for accurate dosing, while peristaltic pump options offer gentle handling for sensitive formulations. Servo motor-operated systems enable real-time adjustment of filling parameters, ensuring consistency across production runs.

The filling accuracy achievable with contemporary equipment ranges from ±0.5% to ±1%, meeting pharmaceutical industry precision requirements. Machines in this category can process vials ranging from 2ml to 250ml, with the 1-20ml range representing a standard pharmaceutical dosage format.

Production Performance and Specifications

Production capacity for 1-20ml vials varies based on machine configuration. Entry-level systems operate at approximately 40-60 vials per minute, while high-performance models achieve up to 300+ vials per minute. The VR840 series from specialized manufacturers reaches 400 bottles per minute on 16-head configurations, while aseptic systems can process 4,000-18,000 vials per hour depending on specifications.

Automatic Safety and Control Features

Advanced vial filling machines incorporate multiple automated safety mechanisms. The "No Vial-No Filling" system prevents wastage by halting operations when containers are absent. Similarly, "No Capping-No Filling" and "No Stoppering-No Filling" protocols ensure synchronized operations across filling, capping, and stoppering stations.

PLC touch screen control systems enable real-time monitoring of filling volumes, production speeds, and operational diagnostics. These systems generate electronic production records for regulatory compliance tracking and generate automatic alarms for operational anomalies.

Material Specifications and Contamination Prevention

All contact components are manufactured from AISI SS 316L stainless steel, ensuring compatibility with pharmaceutical liquids and facilitating sterilization. The framework utilizes AISI SS 304 stainless steel, providing structural integrity while maintaining cGMP compliance.

The machine architecture minimizes dead ends and difficult-to-clean spots through redesigned unscrambler systems, reducing cross-contamination risk. Machines are designed for operation within sterile environments with laminar flow protection, incorporating optional Class 100 clean room configurations.

Manufacturer Advantages

Leading manufacturers in this sector offer several competitive advantages:

Design Flexibility: Modular construction enables quick changeovers between bottle types and liquid formulations within 30 minutes, minimizing production downtime.

Regulatory Alignment: Equipment meets cGMP standards and ISO 13485 requirements, with materials certified as FDA food-grade. Optional aseptic configurations comply with proposed and current regulatory frameworks.

Customization Options: Machines accommodate various filling heads (2-12 nozzles), enabling scalability from pilot to production scale. Optional features include Class A laminar air flow systems, nitrogen purging capabilities, integrated liquid storage tanks, weighing systems, and visual inspection modules.

Operational Efficiency: Variable frequency drives enable speed adjustment without mechanical modifications. Digital vial counters provide real-time production output tracking, while on-line mechanisms facilitate continuous operation.

Precision Engineering: Eccentric pre-gassing and post-gassing systems, combined with non-return valve syringes, eliminate volume variation and ensure consistent dosing across production runs.